Published June 2001
by Uppsala Universitet .
Written in English
|The Physical Object|
|Number of Pages||69|
Abstract. Liposomes that destabilize at mildly acidic pH are efficient tools for delivering water-soluble drugs into the cell cytoplasm. However, their use in vivo is limited because of their rapid uptake from circulation by the reticuloendothelial system. Lipid-anchored polyethylene glycol (PEG-PE) prolongs the circulation time of liposomes by steric stabilization. These ﬁndings support the use of sterically stabilized cationic liposomes to signiﬁcantly enhance the therapeutic ef ﬁcacy of CpG ODN. The Journal of . Volume , Issue 2, 14 August , Pages Biochimica et Biophy Sterically stabilized liposomesCited by: The blood clearance curve of In encapsulated in sterically stabilized pH-sensitive liposomes (Fig. 5A) was similar to that of previously developed liposomes with prolonged circulation time, and a substantial percentage of liposomes (%) remained in the blood after 24 h. In contrast, the radioactive marker encapsulated in regular pH.
Lipids and lipid-based delivery vehicles, namely liposomes, micelles, and micro/nano bubbles have become the most researched and clinically applied area in the field of nanomedicine. Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes. Woodle MC(1), Matthay KK, Newman MS, Hidayat JE, Collins LR, Redemann C, Martin FJ, Papahadjopoulos D. Author information: (1)Liposome Technology, Inc., Menlo Park, CA Cited by: a year-old boy is brought to the pediatrician’s office in mid summer because of an itchy, blistering rash on his calves and forearms. the rash developed 24 hours after he returned from a weekend boy scout camping trip. the pediatrician suspects the lesion is caused by poison ivy. if the doctor is correct, which one of the following is not a prominent component in the . Preparation of Liposomes The choice of lipids for liposome research is entirely dependent on the system to be studied. Biological assays may require mixtures of lipids while pharmacokinetics of drug delivery are dramatically affected by the phase .
Thin Layer Chromatography (TLC) Analysis of Phospholipids. Procedure for TLC of synthetic PIPs. TLC Solvent Systems – Lipid Migration. Detection Methods for Thin Layer Chromatography. Fatty Acid Analysis of Phospholipids by GC/FID. Determination of Phospholipid Oxidation by UV/VIS Spectroscopy. Fatty Acid Composition. Physical Properties. A liposome is a spherical vesicle having at least one lipid liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs. Liposomes can be prepared by disrupting biological membranes (such as by sonication).. Liposomes are most often composed of phospholipids, especially phosphatidylcholine, but may also include other lipids, such as egg. Solubilized paclitaxel amount increased linearly with an increase in lipid concentration. A therapeutically relevant lipid concentration (15 mM) of SSMM solubilized ± 48μg/ml of paclitaxel. Paclitaxel in the absence of sufficient SSM aggregated to Cited by: The Elsevier book-series Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes and lipid self-assemblies from the micro- to the lipid bilayers are widely studied due to their ubiquity in nature and find their .